I was going to carry bear spray on my Alaska hunt a couple of years ago, but it was a hassle getting it on the plane, and I just carried a borrowed .44 Super Blackhawk.
I did not feel confident AT ALL in that sidearm, as I hadn't shot it and gotten comfortable with it beforehand. A few months ago, I picked up one of Ruger's new 3 3/4" Bisley Lipsey .44 Super Blackhawks, and I think it's going to be the perfect sidearm for me as a bowhunter. Depending on the situation, spray will always be considered as well, but I just feel better with a good, loud, and capable pistol on me. It will handle the 340 grain Buffalo Bore cartridges well. I'll shoot that gun a lot in the field before relying on it, too.