Best advice
1) Don't try to do too much. Alaska is 5 times the size of California, no way your going to do it all in one trip.
2) Get away from the road system, unless you love crowds it is the only way your going to enjoy fishing here.
3) Stay flexible never can tell when momma nature will destroy the best laid plans of you and the wife
4) As with any travel hook up with a local if you can, we know the good places, restaurants and how to get away from the crowds.

I'm in Palmer drop me a PM if you'll be passing through, you'll find long time Alaskans are friendly to a fault. If you do find yourself in Homer Dave is the guy to talk to, and a good friend of mine. Like Fletcher I wouldn't combat fish if my life depended on it, however there are ways to avoid the crowds, and places to fish in peace.

If you want king salmon  you better be here in June.  Most of the state closes down in July specifically july 4th weekend.

Places to go?  Jeesh for a fisherman the pennisula and the valley are hard places to beat....literally world class rainbow fishing and some sweet king salmon fishing (on the weekends).... oh and the king salmon fishing is CROWDED!!!  

July is good for russian reds.  

Grayling in the interior it's hard to beat the delta clearwater if you can get your hands on a raft/canoe for a day or three...about as good as it gets.   The upper chena also is a pretty dang good producer if you ask me.

If you are planning on the thought of hunting the later the better.  There is a early caribou season up north.   Can be hit or miss....what's more to say it's caribou hunting.  Definatly a worth while trip if you have the time and cash to finance it.  

Specifics?  

Kenai bows!!!  That's where I'd start!!!!  cough cough ouch don't twist so hard.  Shame I'll be guiding again in southeast or I'd take ya in a heart beat.

Homer is a 5 hour drive from Anchorage. Kenia is about 3 hours on the way to Homer. Seward is about 2.5 hours South of Anchorage but only an hour detour if you're going to Kenia. Girdwood is an hour South. Denali is 5 hours North. Talkeetna is 2 hours on the way to Denali. Fairbanks is 7 hours North. If you spend half your time driving you'll still have a trip of a lifetime.
I always wanted to see Alaska so I moved up here.

Speaking of that. Jerry, if you come up here again and don't stop in and say hi I'm gonna turn my girls loose on ya.

Uh, you will require bug protection. No, seriously. Ask others about them.

My wife and I flew into Anchorage, rented a van and stayed at the Salmon Haus Bed and Breakfast in Kenei the first week of July. We took a one day cruise out of Seward to see the ice fields and the whales. Drove to Homer to see the big Halibut (Bonnie was not interested in fishing off shore)and did a drift fishing trip down the Kenai, where my better half caught a 63 pound King Salmon that now resides on my wall in the trophy room. Don't miss downtown Anchorage and Danali for sure. It is the growing season in July and August and you will be amazed at the flowers that will be in full bloom. Have fun and don't feed the bears.